Geoff Parker

Research Group Leader, Imaging Science and Biomedical Engineering (ISBE) Research Group. ISBE represents much of the imaging-based research at the University of Manchester, with a focus on quantitative imaging methods and image analysis applied to medicine. ISBE is part of the Medical School of the Faculty of Medical and Human Sciences at the University of Manchester.

 

In addition to this page I also have a University of Manchester Medical School web page with some additional information here.

 

 

RESEARCH INTERESTS

My two main areas of research are dynamic contrast-enhanced MRI (DCE-MRI) and central nervous system connectivity studies using MR diffusion tractography methods. Current research projects include:

  • Quantitative DCE-MRI of tumours and inflammatory conditions
  • Tumour perfusion and oxygenation
  • Image registration
  • Development and application of quantitative fibre tracking using MR diffusion imaging

Publications

Click here for a list of my journal publications

Click here for a list of book chapters

Click here for a list of international meeting proceedings

Click here for a list of UK meeting proceedings

QBI LABORATORY

I head the Quantitative Biomedical Imaging Laboratory within ISBE. The QBI Lab focuses on quantitative MRI characterization of tumour microstructure and physiology. We have also been involved in quantitative imaging in inflammatory conditions and in quantitative musculoskeletal morphological imaging. Our research is a mix of methodological innovation and collaborative research projects with clinicians and industry. We currently enjoy funding from the pharmaceutical industry, Cancer Research UK, and UK research councils, with on-going research projects in:

·        Quantitative DCE-MRI in oncology

·        Tracer kinetic modeling methods

·        Image registration

·        Tumour growth patterns

·        Tumour oxygenation

The QBI Lab has also participated in a number of phase I clinical trials of anti-angiogeneic and antivascular agents using DCE-MRI in the quantification of tumour microvascular function.

For more information please contact Geoff Parker or navigate to the QBI Lab website.

Vacancies in Imaging Biomarkers Methods Development

The QBI Lab currently has two vacancies for researchers to work on the development of imaging biomarker of tumour vascularisation and tumour oxygenation/hypoxia. Please contact Geoff Parker for more details.

We also have a vacancy for a 4-year PhD studentship involving the development of methods to measure lung compliance using magnetic resonance imaging (start Sept 2008). Please contact Geoff Parker or Josephine Naish for more details.

DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN ONCOLOGY

We have recently published a book on DCE-MRI in oncology:

Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology (Medical Radiology Series)
Editors: Alan Jackson, David Buckley, Geoffrey J.M. Parker

Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. K

ISBN: 3540423222

 

 

Synopsis: Dynamic contrast-enhanced MRI is now established as the methodology of choice for the assessment of tumor microcirculation in vivo. This is assisting clinical practitioners in the management of patients with solid tumors and is finding prominence in the assessment of tumor treatments, including anti-angiogenics, chemotherapy, and radiotherapy. In this book, targeted at both clinical practitioners and basic scientists, the principles of the methods, their practical implementation, and their application to specific tumor types are discussed by the leading authorities in the field today. The book will serve as an invaluable single-volume reference covering all the latest developments in contrast-enhanced oncological MRI.

 

                                                                                         

 

 

 

Table of contents

 

  • An introduction to dynamic contrast-enhanced MRI in oncology (I.S. Gribbestad et al.)
  • Contrast agents for magnetic resonance imaging (T.P.L. Roberts & M.D. Noseworthy)
  • The role of blood pool contrast agents in the study of tumor pathophysiology (L.S. Fournier & R.C. Brasch)
  • Quantification of dynamic susceptibility contrast T2* MRI in oncology (F. Calamante)
  • Measuring contrast agent concentration in T1-weighted dynamic contrast-enhanced MRI (D.L. Buckley & G.J.M. Parker)
  • Tracer kinetic modelling for T1-weighted DCE-MRI (G.J.M. Parker & D.L. Buckley)
  • Imaging techniques for dynamic susceptibility contrast-enhanced MRI (M. Pedersen, P. van Gelderen, & C.T.W. Moonen)
  • Consensus recommendations for acquisition of dynamic contrast-enhanced MRI data in oncology (J. Evelhoch)
  • Dynamic contrast-enhanced MRI in cerebral tumours (X.P. Zhu K.L. Li, & A. Jackson)
  • Dynamic magnetic resonance imaging in breast tumours (M.-L. W. Ah-See & A. R. Padhani)
  • Dynamic contrast enhanced MR imaging for predicting tumor control in patients with cervical cancer (J.F. Montebello et al.)
  • Dynamic contrast-enhanced MRI of prostate cancer (A.R. Padhani)
  • Dynamic contrast-enhanced MR imaging in musculoskeletal tumors (J.S. Taylor & W.E. Reddick)
  • Dynamic contrast-enhanced MRI in the liver (A. Jackson & D.A. Nicholson)
  • The use of dynamic contrast-enhanced MRI in multi-centre trials with particular reference to breast cancer screening in women at genetic risk (M.O. Leach)
  • Applications of dynamic contrast-enhanced MRI in oncology drug development (G.C. Jayson & J.C. Waterton)



 
Geoff Parker
Professor of Biomedical Imaging
Imaging Science & Biomedical Engineering
Stopford Building
University of Manchester
Oxford Road
Manchester M13 9PT
UK

geoff.parker@manchester.ac.uk

Last edited GJMP 7th December 2007.